Kynurenine-Tryptophan Ratio

    Researchedby:
    Mike Murray
    Last Updated: November 16, 2022

    Tryptophan is a precursor of melatonin and serotonin. One way it is degraded in the body is by the enzyme indoleamine 2,3 deoxygenase — which is stimulated by inflammation — to produce kynurenine. The ratio of kynurenine to tryptophan is a measure of tryptophan degradation, with a lower value suggesting decreased tryptophan degradation.

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    Examine Database References

    1. Tart Cherry Juice - Glyn Howatson, Phillip G Bell, Jamie Tallent, Benita Middleton, Malachy P McHugh, Jason EllisEffect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep qualityEur J Nutr.(2012 Dec)