Benfotiamine

    Researchedby:
    Kamal Patel
    Last Updated: November 17, 2022

    Benfotiamine is a relative of the vitamin Thiamine (B1) that appears to have a therapeutic role in pain reduction and diabetic complications (neuropathies and nephropathies); confers bioavailable Vitamin B1 after oral ingestion.

    examine-databaseExamine Database

    Benfotiamine is most often used for .

    232 participants in 4 trials

    What are other names for Benfotiamine

    Note that Benfotiamine is also known as:
    • S-{(Z)-2-{(4-amino-2-methylpyrimidin-5-yl) methyl-formylamino}-5-phosphonooxypent-2-en-3-yl} benzenecarbothioate
    Benfotiamine should not be confused with:
    • Sulbutiamine (a molecule made from two Thiamin molecules; very different actions though)

    Dosage information

    Benfotiamine is commonly taken at the oral dose of 300-600mg over the course of the day, usually in two divided doses with meals (150mg or 300mg twice daily).

    Supplements Demystified: Get Our Unbiased, Evidence-Based Guide

    Examine Database: Benfotiamine

    What works and what doesn't?

    Unlock the full potential of Examine

    Get started

    Examine Database References

    1. Proteinuria - Alkhalaf A, Klooster A, van Oeveren W, Achenbach U, Kleefstra N, Slingerland RJ, Mijnhout GS, Bilo HJ, Gans RO, Navis GJ, Bakker SJA double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathyDiabetes Care.(2010 Jul)
    2. Nerve Repair - Fraser DA, Diep LM, Hovden IA, Nilsen KB, Sveen KA, Seljeflot I, Hanssen KFThe effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trialDiabetes Care.(2012 May)
    3. Advanced Glycation End Products - Alkhalaf A, Kleefstra N, Groenier KH, Bilo HJ, Gans RO, Heeringa P, Scheijen JL, Schalkwijk CG, Navis GJ, Bakker SJEffect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathyPLoS One.(2012)
    4. Protection from Smoking - Stirban A, Nandrean S, Kirana S, Götting C, Veresiu IA, Tschoepe DBenfotiamine counteracts smoking-induced vascular dysfunction in healthy smokersInt J Vasc Med.(2012)