1.
Fat-Burning Potential
Rauwolscine, or {3H}Rauwolscine, is an antagonist of alpha-1 and alpha-2 adrenergic receptors (more so the latter).[1] This is the same mechanism by which yohimbine acts.
2.
Blood Vessel and Cardiac Health
3.
Serotonergic Effects
Like yohimbine, rauwolscine is an agonist of 5-HT1a/b receptors and induce serotonin-like effects. While yohimbine has more affinity for the receptor, rauwolscine has a lower IC50 value (meaning it can saturate more receptors at the same dose) and can be seen as slightly more potent in serotonergic activity.[3][4]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor|published=1998 Jan|authors=Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL|journal=Naunyn Schmiedebergs Arch Pharmacol]
References
- ^J C Doxey, A C Lane, A G Roach, N K VirdeeComparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthineNaunyn Schmiedebergs Arch Pharmacol.(1984 Feb)
- ^Rockhold RW, Gross FYohimbine diastereoisomers: cardiovascular effects after central and peripheral application in the ratNaunyn Schmiedebergs Arch Pharmacol.(1981 Jan)
- ^Arthur JM, Casañas SJ, Raymond JRPartial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptorsBiochem Pharmacol.(1993 Jun 9)
- ^[3H